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Graft-versus-host disease
1Department of Pediatrics, University of Florida College of Medicine, Gainesville.
Graft-versus-host disease is an uncommon but serious illness, caused by foreign, immunocompetent T lymphocytes attacking an immunoincompetent host. It is encountered following allogeneic bone marrow transplantation and in congenital cellular immunodeficiency disorders. Diagnostic features, clinical grading system, therapy and prevention are reviewed.
Graft-versus-host disease is an uncommon but serious illness, caused by foreign, immunocompetent T lymphocytes attacking an immunoincompetent host. It is encountered following allogeneic bone marrow transplantation and in congenital cellular immunodeficiency disorders. Diagnostic features, clinical grading system, therapy and prevention are reviewed.