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Central corneal thickness in children with intellectual disability: a controlled study
Arsen Akinci1, Ozgur Oner, Kerim Munir
1Kudret Eye Hospital, Ankara, Turkey. arsenakinci@yahoo.com
Cornea
|December 22, 2009
Summary
Children with intellectual disability (ID) have thicker central corneal thickness (CCT) than healthy children. Syndromic etiology is linked to higher CCT in these individuals.
Area of Science:
- Ophthalmology
- Genetics
- Pediatrics
Background:
- Intellectual disability (ID) can be associated with various medical conditions.
- Central corneal thickness (CCT) is an important ocular biometric parameter.
- Understanding ocular characteristics in ID populations is crucial for comprehensive care.
Purpose of the Study:
- To measure central corneal thickness (CCT) in children with intellectual disability (ID).
- To investigate the relationship between ID-related factors and CCT.
Main Methods:
- Ultrasound pachymetry was used to assess CCT in 77 children with ID and 38 controls.
- ID subjects were categorized by severity (mild, moderate, severe) and etiology (syndromic, nonsyndromic).
- Statistical analyses included ANOVA, chi-test, and linear regression.
Main Results:
- Children with ID exhibited significantly higher CCT (549.7 ± 21.4 µm) compared to controls (521.6 ± 16.9 µm).
- Syndromic etiology was identified as a significant predictor of increased CCT in the ID group.
- The observed increase in CCT, while statistically significant, was not deemed clinically significant.
Conclusions:
- Children with intellectual disability demonstrate increased central corneal thickness.
- Syndromic cause is the sole predictor of elevated CCT in children with ID.
- The CCT findings in ID children are statistically significant but not clinically relevant.
