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Related Concept Videos

Tension Response at Adherens Junctions01:26

Tension Response at Adherens Junctions

The adherens junctions that anchor cells together are multi-protein complexes that dynamically adapt to mechanical stimuli such as tensile forces and shear stress. Mechanosensory proteins in these junctions can sense such mechanical stimuli and undergo a shift in their conformation, resulting in an altered function — a process called mechanotransduction.
α-Catenin as a Mechanosensory Protein
The α-catenin of adherens junctions is an allosteric protein with three VH (vinculin homology) domains...
Adhesion01:14

Adhesion

Adhesion occurs when one type of molecule is attracted to a different molecule. Water exhibits adhesive properties in the presence of polar surfaces, such as glass or cellulose in plants. For instance, when water is poured into a glass, the positively charged hydrogen molecules of water are more attracted to the negatively charged oxygen molecules in the silica than to the oxygen in neighboring water molecules.
Capillary action is a result of water’s adhesive tendencies. When a narrow glass...

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Related Experiment Video

Updated: Jun 17, 2026

Simple, Affordable, and Modular Patterning of Cells using DNA
08:59

Simple, Affordable, and Modular Patterning of Cells using DNA

Published on: February 24, 2021

Electrically controlled DNA adhesion.

Matthias Erdmann1, Ralf David, Ann Fornof

  • 1Chair for Applied Physics and Center for NanoScience, Ludwigs-Maximilians-Universität Munich, Amalienstrasse 54, 80799 Munich, Germany.

Nature Nanotechnology
|December 22, 2009
PubMed
Summary
This summary is machine-generated.

Controlling DNA adhesion to surfaces is key for biotechnology. Researchers found that electrode potential can tune DNA

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Last Updated: Jun 17, 2026

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Design and Synthesis of a Reconfigurable DNA Accordion Rack
07:44

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

Area of Science:

  • Biotechnology
  • Surface Science
  • Molecular Biophysics

Background:

  • Controlling polyelectrolyte interactions with charged surfaces is crucial for biotechnological applications.
  • Previous work involved measuring single polymer desorption forces using atomic force microscopy.

Purpose of the Study:

  • To investigate the external control of DNA adhesion on gold electrodes.
  • To understand the influence of surface modification and electrode potential on DNA adsorption forces.

Main Methods:

  • Atomic Force Microscopy (AFM) to measure desorption forces.
  • Utilizing gold electrodes modified with self-assembled monolayers (SAMs) with different terminal groups (e.g., -OH, -NH2).
  • Applying external electrode potentials (e.g., +0.5 V vs. Ag/AgCl) to modulate DNA adhesion.

Main Results:

  • DNA adhesion on OH-terminated electrodes was induced by positive potentials, with adhesion forces up to 25 pN.
  • Negative potentials suppressed DNA adsorption.
  • Measured forces agreed with Gouy-Chapman theory, considering DNA backbone and terminal phosphate charges.
  • Similar force modulation was observed on NH2-terminated electrodes.

Conclusions:

  • Electrode potential offers external control over DNA adhesion to modified gold surfaces.
  • Surface composition and applied potential are critical factors in DNA-surface interactions.
  • Findings support the development of DNA-based biochips and supramolecular assemblies.