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Updated: Jun 17, 2026
Synthesis and Evaluation of a Ruthenium-based Mitochondrial Calcium Uptake Inhibitor
Published on: October 26, 2017
Synthesis, molecular structure and evaluation of new organometallic ruthenium anticancer agents
Kenneth D Camm1, Ahmed El-Sokkary, Andrew L Gott
1Department of Chemistry, University of Leeds, Leeds, LS2 9JT, UK.
Abstract:
A number of new ruthenium compounds have been synthesised, isolated and characterised, which exhibit excellent cytotoxicity against a number of different human tumour cell lines including a defined cisplatin resistant cell line and colon cancer cell lines. Addition of hydrophobic groups to the ruthenium molecules has a positive effect on the cytotoxicity values. Evidence is provided that, after incubation of a ruthenium compound with a 46 mer oligonucleotide duplex and subsequent nuclease treatment, ruthenium is bound to a guanine residue.
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