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Updated: Jun 17, 2026

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Published on: October 1, 2007

An automated, pre-programmed, multiplexed, hydraulic microvalve.

Jitae Kim¹, Dafeng Chen, Haim H Bau

¹Department of Mechanical Engineering and Applied Mechanics, University of Pennsylvania, Philadelphia, PA 19104-6315, USA.

|December 22, 2009

Summary

This summary is machine-generated.

This study introduces a novel automated hydraulic valve actuator for precise fluid control in lab-on-a-chip devices. The system utilizes computer-controlled rollers to manage hydraulic liquid, enabling sequential three-way valve actuation efficiently.

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Area of Science:

Biotechnology
Mechanical Engineering
Fluidics

Background:

Pneumatic valves are common in lab-on-a-chip devices but can be complex to control.
Existing hydraulic control systems may be expensive or lack precise programmability.
There is a need for cost-effective and automated fluid control solutions in microfluidics.

Purpose of the Study:

To develop and characterize an automated, pre-programmed, multiplexed hydraulic valve actuator.
To demonstrate the valve's capability for sequential three-way actuation.
To evaluate the valve's performance and utility in microfluidic applications, specifically a micro thermal cycler.

Main Methods:

Design and fabrication of a membrane-based, normally open hydraulic valve.
Development of a roller-based topology system for line pressure control.
Assembly of multiple rollers into a single carriage for manual or computer-controlled actuation.
Testing of a valve manifold and roller actuators for sequential three-way valve actuation.

Main Results:

Successful demonstration of a pre-determined sequence of three-way valve actuation.
Evaluation of the hydraulic valve's performance characteristics.
Demonstration of the valve's utility in operating a micro thermal cycler.

Conclusions:

The described hydraulic valve actuator offers an inexpensive and effective method for automated flow control.
The system can be operated manually or under computer control, enhancing its versatility.
This technology shows significant potential for advancing lab-on-a-chip devices and microfluidic applications.