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Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
Imaging Studies for Cardiovascular System IV: CMRI01:21

Imaging Studies for Cardiovascular System IV: CMRI

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Cardiomyopathy IV: Restrictive Cardiomyopathy

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Related Experiment Videos

CRP in cardiovascular disease.

Mahir Karakas1, Wolfgang Koenig

  • 1Department of Internal Medicine II - Cardiology, University of Ulm Medical Center, Ulm, Germany.

Herz
|December 22, 2009
PubMed
Summary

High-sensitivity C-reactive protein (hsCRP) identifies individuals at elevated cardiovascular risk, even with normal cholesterol. Statin therapy, as shown in the JUPITER trial, significantly reduces cardiovascular events in these patients.

Area of Science:

  • Cardiology
  • Biomarkers
  • Preventive Medicine

Background:

  • Traditional cardiovascular risk factors inadequately identify all at-risk individuals.
  • High-sensitivity C-reactive protein (hsCRP) is a widely studied blood biomarker for cardiovascular risk.
  • While associations exist, the causal link between CRP and coronary heart disease (CHD) is debated, with Mendelian randomization studies suggesting it may not be causal.

Purpose of the Study:

  • To evaluate if individuals with normal low-density lipoprotein cholesterol but elevated hsCRP levels represent a high-risk population.
  • To determine if statin treatment benefits this specific high-risk group.

Main Methods:

  • The JUPITER trial randomized 17,802 apparently healthy individuals to receive either 20 mg of rosuvastatin daily or a placebo.

Related Experiment Videos

  • Participants had normal low-density lipoprotein cholesterol levels but elevated hsCRP.

    • Main Results:

    • Rosuvastatin significantly reduced the incidence of major cardiovascular events by 44% compared to placebo.
    • The primary endpoint rates were 0.77 per 100 person-years for rosuvastatin and 1.36 per 100 person-years for placebo.
    • hsCRP may serve as an integrative marker, identifying high-risk subjects by reflecting overall inflammatory burden.

    Conclusions:

    • Elevated hsCRP in individuals with normal LDL cholesterol identifies a population that benefits from statin therapy.
    • The JUPITER trial findings support the clinical utility of hsCRP in cardiovascular risk assessment and prevention.
    • hsCRP's role in identifying high-risk individuals warrants further consideration in clinical practice.