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Updated: Jun 17, 2026

Assays for Validating Histone Acetyltransferase Inhibitors
Published on: August 6, 2020
HDAC Inhibitors--CHI's Third Annual Conference
1Virginia Commonwealth University, Massey Cancer Center, 401 College Street, PO Box 980037, Richmond, VA 23298-0037, USA. rrrosato@vcu.edu
New therapeutic developments in HDAC inhibitors were discussed for treating cancer, inflammation, and CNS diseases. Several investigational drugs, including compounds from Karus Therapeutics, Orchid Research Laboratories, and EnVivo Pharmaceuticals, were highlighted.
Area of Science:
- Pharmacology and Therapeutics
- Oncology
- Neuroscience
Background:
- Histone deacetylase (HDAC) inhibitors represent a promising class of therapeutic agents.
- Significant advancements in HDAC inhibitor research have been presented at recent scientific meetings.
Purpose of the Study:
- To summarize key findings and therapeutic developments in the field of HDAC inhibitors.
- To highlight novel investigational compounds and their potential applications.
Main Methods:
- Review of selected presentations from the HDAC Inhibitors meeting in Boston.
- Focus on therapeutic strategies for cancer, inflammation, and central nervous system (CNS) diseases.
Main Results:
- Discussion of new therapeutic developments in HDAC inhibitor research.
- Highlighting investigational drugs such as OCID-4681 and EVP-0334.
- Mention of compounds under evaluation by Karus Therapeutics Ltd.
Conclusions:
- HDAC inhibitors show potential for treating a range of diseases, including cancer, inflammation, and neurodegenerative disorders.
- Ongoing research and development of novel HDAC inhibitors are crucial for future therapeutic advancements.
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