Related Experiment Video
Updated: Jun 17, 2026

Cost-Efficient Transcriptomic-Based Drug Screening
Published on: February 23, 2024
Transcriptome analysis in benefit-risk assessment of micronutrients and bioactive food components
Jaap Keijer1, Yvonne G J van Helden, Annelies Bunschoten
1Human and Animal Physiology, Wageningen University, 6700 AH Wageningen, The Netherlands. jaap.keijer@wur.nl
Abstract:
The establishment of functional effects due to variation in concentrations of micronutrients in our diet is difficult since they are often not immediately recognized as being healthy or unhealthy. Indeed, effects induced by micronutrients are hard to identify and therefore the establishment of the recommended daily intake, the optimal intake and the upper limit pose a challenge. For bioactive food components this is even more complicated. Whole-genome transcriptome analysis is highly suitable to obtain unbiased information on potential affected biological processes on a whole-genome level. Here, we will describe and discuss several aspects of transcriptome analysis in benefit-risk assessment, including effect size, sensitivity and statistical power, that have to be taken into account to faithfully identify functional effects of micronutrients and bioactive food components.
Related Concept Videos
Bioavailability Study Design: Healthy Subjects Versus Patients
Bioavailability: Influencing Factors
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Bioavailability: Overview
Bioavailability: Overview
Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems