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Published on: December 2, 2011
Translational systems biology and voice pathophysiology
Nicole Y K Li1, Katherine Verdolini Abbott, Clark Rosen
1Department of Communication Science and Disorders, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
The Laryngoscope
|December 22, 2009
Summary
Evidence-based medicine (EBM) using large trials has limitations for personalized care. Systems biology offers a complementary approach to improve patient outcomes in voice research by modeling biological complexity.
Area of Science:
- Biomedical Research
- Computational Biology
- Translational Science
Background:
- Personalized medicine aims to tailor healthcare to individual needs.
- Evidence-based medicine (EBM) relies on large population studies, which may not apply to individuals due to biological variability.
- Tackling biological complexity is crucial for improving patient care.
Purpose of the Study:
- To review the advantages and disadvantages of Evidence-based Medicine (EBM).
- To discuss systems biology as an alternative approach.
- To present the utility of systems biology in clinical voice research.
Main Methods:
- This study is a tutorial.
- A literature review and discussion were conducted.
Main Results:
- Translational systems biology can overcome EBM limitations in voice and other health domains.
- Mathematical modeling in systems biology quantifies complex biological processes in voice pathophysiology.
- Systems biology is applicable to phonotrauma and vocal fold trauma, supporting personalized medicine.
Conclusions:
- Vocal health evidence should extend beyond population-based methods to include complexity and systems interactions.
- Systems biology is vital for implementing personalized medicine in voice care.
- This approach has broader implications for personalized medicine beyond voice care.
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