Related Experiment Video
Updated: Jun 17, 2026

10:27
Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
[Dermatomyositis and pregnancy: a case in Gabon]
J Iba-Ba1, S Mayi-Tsonga, R Ibouili Bignoumba
1Service de Médecine A, Centre Hospitalier de Libreville, Gabon.
Medecine Tropicale : Revue Du Corps De Sante Colonial
|December 23, 2009
Summary
A dermatomyositis case in a 30-year-old African woman resulted in a successful pregnancy without immunosuppressive therapy. The baby was born prematurely at 32 weeks via caesarean section.
Area of Science:
- Obstetrics and Gynecology
- Rheumatology
- Dermatology
Background:
- Dermatomyositis is a rare idiopathic inflammatory myopathy.
- Pregnancy in women with autoimmune diseases presents unique challenges.
- Management of dermatomyositis during pregnancy often involves immunosuppressive agents.
Observation:
- A 30-year-old African woman with dermatomyositis achieved a successful pregnancy.
- The patient did not receive any immunosuppressive treatment during her pregnancy.
- The pregnancy was complicated by premature labor, necessitating delivery at 32 weeks gestation.
Findings:
- Successful pregnancy and delivery in a patient with dermatomyositis.
- Absence of immunosuppressive treatment did not preclude a positive pregnancy outcome.
- Premature delivery at 32 weeks gestation, consistent with some pregnancy complications in autoimmune disorders.
Implications:
- This case suggests that successful pregnancy outcomes in dermatomyositis may be achievable without immunosuppression.
- Highlights the importance of individualized management strategies for pregnant patients with autoimmune conditions.
- Further research is needed to understand the long-term effects on both mother and child.
Related Concept Videos
Leishmaniasis
Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...
Skin Diseases and Disorders
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Development of Immunocompetence
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Teratogenicity
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
Transcytosis of IgG
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
Acne Infection
Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...