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Compact Quantum Dots for Single-molecule Imaging
Published on: October 9, 2012
InAs(ZnCdS) quantum dots optimized for biological imaging in the near-infrared
Peter M Allen1, Wenhao Liu, Vikash P Chauhan
1Massachusetts Institute of Technology, Department of Chemistry, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
Journal of the American Chemical Society
|December 23, 2009
Abstract:
We present the synthesis of InAs quantum dots (QDs) with a ZnCdS shell with bright and stable emission in the near-infrared (NIR, 700-900 nm) region for biological imaging applications. We demonstrate how NIR QDs can image tumor vasculature in vivo at significantly deeper penetration depths and with higher contrast than visible emitting CdSe(CdS) QDs. Targeted cellular labeling is also presented and may enable multiplexed and low autofluorescence cellular imaging.

