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Preparation and Gene Modification of Nonhuman Primate Hematopoietic Stem and Progenitor Cells
Published on: February 15, 2019
Bone marrow-targeted liposomal carriers: a feasibility study in nonhuman primates
Keitaro Sou1, Beth Goins, Michelle M Leland
1Center for Advanced Biomedical Sciences, Waseda University (TWIns), Tokyo 162-8480, Japan. so@kurenai.waseda.jp
Nanomedicine (London, England)
|December 23, 2009
Summary
Novel liposomes effectively target bone marrow in rhesus monkeys, demonstrating high uptake. This validates the potential of these targeted vesicles for clinical applications in bone marrow drug delivery.
Area of Science:
- Nanotechnology
- Biomedical Engineering
- Pharmacology
Background:
- A novel surface-modified lipid vesicle (liposome) formulation demonstrated high bone marrow targeting in rabbits.
- Bone marrow is a critical site for hematopoiesis, making targeted drug delivery systems highly valuable.
Purpose of the Study:
- To evaluate the efficacy of previously developed bone marrow-targeted liposomes in rhesus monkeys.
- To assess the relevance of these liposomes in a primate model closer to human physiology.
Main Methods:
- Liposomes (216 +/- 21 nm diameter) were formulated with DPPC, cholesterol, anionic amphiphile, and poly(ethylene glycol)-DSPE.
- Vesicles were loaded with glutathione and labeled with technetium-99m ((99m)Tc) for imaging.
Main Results:
- Intravenous administration of (99m)Tc-labeled liposomes in rhesus monkeys showed significant bone marrow uptake.
- Scintigraphic imaging estimated approximately 70% of the injected dose localized to the bone marrow.
Conclusions:
- The study confirms effective bone marrow targeting of the liposomes in a relevant primate model.
- These findings enhance the feasibility of clinical applications for this bone marrow-specific drug delivery system.
