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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...
Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...
Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Type I Diabetes I: Introduction01:12

Type I Diabetes I: Introduction

Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1 diabetes is an...

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Related Experiment Video

Updated: Jun 17, 2026

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

Metabolic changes in autoimmune diseases.

Karsten Seeger1

  • 1Institute of Chemistry, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany. karsten.seeger@chemie.uni-luebeck.de

Current Drug Discovery Technologies
|December 23, 2009
PubMed
Summary
This summary is machine-generated.

Metabolomics, the study of metabolites, offers a less complex yet informative approach to understanding disease mechanisms. This technique is crucial for advancing the study of autoimmune diseases and their complex pathogenesis.

Related Experiment Videos

Last Updated: Jun 17, 2026

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

Area of Science:

  • Metabolomics and its role in understanding complex biological systems.

Background:

  • Metabolomics is an emerging omics technology focused on identifying and quantifying small molecules (metabolites) in biological samples.
  • Metabolomic data is less complex than genomics or proteomics, offering potentially greater insights into biological processes.
  • Autoimmune diseases pose significant clinical challenges due to their chronic nature and complex pathogenesis.

Purpose of the Study:

  • To highlight the potential of metabolomics in unraveling the mechanisms of autoimmune diseases.
  • To underscore the current limitations in understanding the role of specific metabolites in autoimmune disease development.

Main Methods:

  • Utilizing metabolomics to detect and quantify metabolites in biological samples.
  • Analyzing existing studies on the metabolome of autoimmune diseases like Crohn's disease and rheumatoid arthritis.

Main Results:

  • Metabolomics provides a valuable, less complex data set compared to other omics approaches.
  • Previous studies have explored the metabolome in various autoimmune conditions.

Conclusions:

  • Metabolomics holds significant promise for advancing our understanding of disease mechanisms, particularly in autoimmune disorders.
  • Further research is needed to fully elucidate the role of metabolites in the pathogenesis of autoimmune diseases.