Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
Phylogenetic Trees03:21

Phylogenetic Trees

Phylogenetic trees come in many forms. It matters in which sequence the organisms are arranged from the bottom to the top of the tree, but the branches can rotate at their nodes without altering the information. The lines connecting individual nodes can be straight, angled, or even curved.The length of the branches can depict time or the relative amount of change among organisms. For instance, the branch length might indicate the number of amino acid changes in the sequence that underlies the...
Phylogenetic Trees03:21

Phylogenetic Trees

Phylogenetic trees come in many forms. It matters in which sequence the organisms are arranged from the bottom to the top of the tree, but the branches can rotate at their nodes without altering the information. The lines connecting individual nodes can be straight, angled, or even curved.The length of the branches can depict time or the relative amount of change among organisms. For instance, the branch length might indicate the number of amino acid changes in the sequence that underlies the...
Microbial Phylogeny01:28

Microbial Phylogeny

Understanding the evolutionary relationships among microorganisms is fundamental to microbial ecology and taxonomy. Phylogenetic trees are essential tools for inferring these relationships, relying primarily on comparative analyses of molecular sequences such as DNA, RNA, or proteins. In microbial studies, these trees typically depict the evolutionary paths of diverse bacterial and archaeal species by mapping genetic differences accumulated over time.Phylogenetic trees are composed of tips,...
Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A ratiometric FRET sensor regulated by amide naphthotubes <i>via</i> simultaneous spatial confinement and spectral red-shift.

Chemical communications (Cambridge, England)·2026
Same author

Clinicopathological and molecular determinants of pancreatic neuroendocrine tumors: toward precision risk stratification.

Journal of translational medicine·2026
Same author

Temporal dynamics of serum Mycoplasma pneumoniae antibodies in patients with acute respiratory infections: a large retrospective study.

Annals of clinical microbiology and antimicrobials·2026
Same author

Adjunct tirofiban treatment after successful endovascular thrombectomy recanalisation in acute anterior circulation ischaemic stroke (ATTRACTION): protocol of a multicentre, prospective, double-blinded, randomised trial.

Stroke and vascular neurology·2026
Same author

Porous SnO<sub>2</sub> Nanofibers Embedded with Hollow Hetero-Metal Oxide Nanospheres for Enhanced Gas Sensing.

ACS applied materials & interfaces·2025
Same author

Ultrasonography of the rectus femoris, a tool to assess the severity of sarcopenia in lung cancer patients: An observational study.

Medicine·2025

Related Experiment Video

Updated: Jun 17, 2026

Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin
08:57

Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin

Published on: August 14, 2018

New method for global alignment of 2 DNA sequences by the tree data structure.

Zhao-Hui Qi1, Xiao-Qin Qi, Chen-Chen Liu

  • 1School of Computer and Information Engineering, Shijiazhuang Railway Institute, Shijiazhuang, Hebei 050043, People's Republic of China. zhqi_yh2004@yahoo.com.cn

Journal of Theoretical Biology
|December 23, 2009
PubMed
Summary

This study presents a novel DNA sequence alignment method using a graphical simple alignment tree (GSA tree). This approach enhances the analysis of DNA sequence alignment for global alignment tasks.

More Related Videos

The ITS2 Database
16:17

The ITS2 Database

Published on: March 12, 2012

A Concoction Pipeline for Generating Molecular Operational Taxonomic Units (MOTUs) Among Riparian and Aquatic Beetles
10:23

A Concoction Pipeline for Generating Molecular Operational Taxonomic Units (MOTUs) Among Riparian and Aquatic Beetles

Published on: July 11, 2025

Related Experiment Videos

Last Updated: Jun 17, 2026

Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin
08:57

Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin

Published on: August 14, 2018

The ITS2 Database
16:17

The ITS2 Database

Published on: March 12, 2012

A Concoction Pipeline for Generating Molecular Operational Taxonomic Units (MOTUs) Among Riparian and Aquatic Beetles
10:23

A Concoction Pipeline for Generating Molecular Operational Taxonomic Units (MOTUs) Among Riparian and Aquatic Beetles

Published on: July 11, 2025

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Genomics

Background:

  • DNA sequence alignment is crucial for understanding genetic relationships and functions.
  • Existing methods may face challenges in efficiency and visualization for complex alignments.

Purpose of the Study:

  • To introduce a new, integrated approach for DNA sequence alignment.
  • To develop a method that visualizes alignment scores and facilitates global alignment.

Main Methods:

  • A three-part method: simple alignment algorithm, largest common substring extension, and graphical simple alignment tree (GSA tree).
  • Graphical representation of DNA sequence scores using a specific scoring equation.
  • Construction of a GSA tree for global alignment of two DNA sequences.

Main Results:

  • The developed approach provides a graphical representation of alignment scores.
  • The GSA tree aids in solving global alignment problems for DNA sequences.
  • Practical examples demonstrate the utility and effectiveness of the proposed method.

Conclusions:

  • The novel approach offers a practical and efficient tool for DNA sequence alignment.
  • The GSA tree visualization enhances the understanding and application of global alignment.
  • This method has potential applications in various areas of genetic research.