Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Role of Hippocampus in Memory

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Greater choroid plexus volume is linked to poor sleep, neurodegeneration, and cognitive deficits in older adults: Evidence from the IGNITE Study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026

Same author

Inflammatory, metabolic, and vascular pathways linking cardiorespiratory fitness to cognition: Results from the IGNITE study.

Brain, behavior, & immunity - health·2026

Same author

Transitions in exercise motive profiles and their association with physical activity adherence among low-active middle-aged adults: An exploratory ancillary analysis.

Psychology of sport and exercise·2026

Same author

A multicomponent behavior change intervention to promote walking in adults after traumatic brain injury: A Pilot Randomized Control Trial.

medRxiv : the preprint server for health sciences·2026

Same author

Physical activity, aerobic fitness, and AD blood biomarkers: The IGNITE study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026

Same author

Feasibility and exploratory cognitive outcomes of three exercise modalities in oldest-old adults in assisted living facilities: A 24-week pilot randomized controlled trial.

Journal of affective disorders·2026

Search research articles

Related Experiment Video

Updated: Jun 17, 2026

Assessing Human Spatial Navigation in a Virtual Space and its Sensitivity to Exercise

Assessing Human Spatial Navigation in a Virtual Space and its Sensitivity to Exercise

Published on: January 26, 2024

Resting hippocampal blood flow, spatial memory and aging.

Susie Heo¹, Ruchika Shaurya Prakash, Michelle W Voss

¹Department of Psychology, University of Illinois, Urbana-Champaign, IL, USA. sheo2@uiuc.edu

|December 23, 2009

Summary

This summary is machine-generated.

Aging impacts cognitive function and cerebral blood flow (CBF). This study found that higher hippocampal blood flow in older adults correlates with better spatial memory, revealing a region-specific link between brain blood supply and cognition.

More Related Videos

Assessing Spatial Memory Impairment in a Mouse Model of Traumatic Brain Injury Using a Radial Water Tread Maze

Assessing Spatial Memory Impairment in a Mouse Model of Traumatic Brain Injury Using a Radial Water Tread Maze

Published on: July 17, 2017

Utilizing the Modified T-Maze to Assess Functional Memory Outcomes After Cardiac Arrest

Utilizing the Modified T-Maze to Assess Functional Memory Outcomes After Cardiac Arrest

Published on: January 5, 2018

Related Experiment Videos

Last Updated: Jun 17, 2026

Assessing Human Spatial Navigation in a Virtual Space and its Sensitivity to Exercise

Assessing Human Spatial Navigation in a Virtual Space and its Sensitivity to Exercise

Published on: January 26, 2024

Assessing Spatial Memory Impairment in a Mouse Model of Traumatic Brain Injury Using a Radial Water Tread Maze

Assessing Spatial Memory Impairment in a Mouse Model of Traumatic Brain Injury Using a Radial Water Tread Maze

Published on: July 17, 2017

Utilizing the Modified T-Maze to Assess Functional Memory Outcomes After Cardiac Arrest

Utilizing the Modified T-Maze to Assess Functional Memory Outcomes After Cardiac Arrest

Published on: January 5, 2018

Area of Science:

Neuroscience
Cognitive Psychology
Gerontology

Background:

Aging is linked to declines in cognitive abilities and reduced cerebral blood flow (CBF).
Previous research often used global measures, leaving regional CBF-cognition relationships in older adults unclear.
The specific association between regional brain perfusion and distinct cognitive functions during aging requires further investigation.

Purpose of the Study:

To investigate the relationship between aging, spatial memory, and resting hippocampal blood flow.
To examine if regional CBF is associated with cognitive performance in younger and older adults.
To explore region-specific CBF-cognition associations in the aging brain.

Main Methods:

Quantified resting cerebral blood flow (CBF) using a novel Flow-Enhanced Signal Intensity (FENSI) technique.
Assessed spatial memory performance in younger and older adult groups.
Analyzed the correlation between hippocampal blood flow and spatial memory within age groups.

Main Results:

Aging was associated with decreased spatial memory and reduced resting CBF.
A positive correlation was observed between hippocampal blood flow and spatial memory performance in older adults.
These findings indicate that increased hippocampal perfusion is linked to enhanced spatial memory in aging.

Conclusions:

Demonstrates a region-specific relationship between cerebral blood flow and cognitive function in the context of aging.
Suggests that localized blood flow in the hippocampus plays a role in maintaining spatial memory performance in older adults.
Provides new insights into the neurobiological mechanisms connecting the aging brain and behavioral changes.