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Prothrombin gene G20210A mutation and obstetric complications

Robert M Silver1, Yuan Zhao, Catherine Y Spong

  • 1From the Departments of Obstetrics and Gynecology at the University of Alabama at Birmingham, Birmingham, Alabama; the University of Chicago, Chicago, Illinois; the University of Cincinnati, Cincinnati, Ohio; the University of Pittsburgh, Pittsburgh, Pennsylvania; the University of Miami, Miami, Florida; The Ohio State University, Columbus, Ohio; the University of Tennessee, Memphis, Tennessee; the University of Texas at San Antonio, San Antonio, Texas; the University of Texas Southwestern Medical Center, Dallas, Texas; Thomas Jefferson University, Philadelphia, Pennsylvania; the University of Utah, Salt Lake City, Utah; Wake Forest University Health Sciences, Winston-Salem, North Carolina; and Wayne State University, Detroit, Michigan; the George Washington University Biostatistics Center, Washington, DC, and the Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD.

Obstetrics and Gynecology
|December 23, 2009
PubMed
Summary

Maternal carriage of the prothrombin gene G20210A mutation is not associated with adverse pregnancy outcomes like pregnancy loss or preeclampsia in low-risk women. These findings question routine screening for this mutation in asymptomatic individuals.

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