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Published on: June 11, 2012
Metformin compared with glyburide in gestational diabetes: a randomized controlled trial
Lisa E Moore1, Diana Clokey, Valerie J Rappaport
1From the Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico.
Objective:
To compare the efficacy of metformin with glyburide for glycemic control in gestational diabetes.
Methods:
Patients with gestational diabetes who did not achieve glycemic control on diet were randomly assigned to metformin (n=75) or glyburide (n=74) as single agents. The primary outcome was glycemic control. Secondary outcomes were drug failure rate and neonatal and obstetric complications.
Results:
In the patients who achieved adequate glycemic control, the mean fasting and 2-hour postprandial blood glucose levels were not statistically different between the two groups. However, 26 patients in the metformin group (34.7%) and 12 patients in the glyburide group (16.2%) did not achieve adequate glycemic control and required insulin therapy (P=.01).
Conclusion:
In this study, the failure rate of metformin was 2.1 times higher than the failure rate of glyburide when used in the management of gestational diabetes (95% confidence interval 1.2-3.9).
Clinical Trial Registration:
ClinicalTrials.gov, www.clinicaltrials.gov, NCT00965991.
Level Of Evidence:
I.
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