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Alternative technique for reducing compound waste during intravitreal injections.

Jefferson Augusto Santana Ribeiro¹, André Messias, Ingrid U Scott

¹Department of Ophthalmology, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, SP, Brazil.

Arquivos Brasileiros De Oftalmologia

|December 23, 2009

Summary

A new intravitreal injection technique using a 29-gauge insulin syringe and a 21-gauge needle significantly reduces medication waste. This method is a viable alternative to standard ranibizumab kit instructions for intravitreal injections.

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Area of Science:

Ophthalmology
Medical Devices
Pharmacology

Background:

Intravitreal injections are crucial for treating various retinal diseases.
Minimizing medication waste during intravitreal injections is essential for cost-effectiveness and patient care.
Standard drug delivery kits may result in significant residual medication volumes.

Purpose of the Study:

To describe a novel intravitreal injection technique utilizing a 29-gauge insulin syringe and a 21-gauge needle.
To compare medication waste between the novel technique and the standard ranibizumab (Lucentis) kit instructions.

Main Methods:

The novel technique (PT) used a 29-gauge insulin syringe with a 21-gauge aspiration needle and a 29-gauge injection needle.
The standard technique (LK) used the ranibizumab kit's components: a tuberculin syringe, an 18-gauge aspiration needle, and a 30-gauge injection needle.

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Residual volumes in needles and syringe-needle complexes were measured using a precision balance and converted to milliliters.

Main Results:

The PT technique resulted in significantly lower residual volumes in aspiration needles (0.0034 ± 0.0016 ml) compared to the LK technique (0.0579 ± 0.0011 ml) (p<0.01).
Residual volumes in the syringe-needle complexes were also significantly lower with the PT technique (0.0056 ± 0.0011 ml) versus the LK technique (0.0906 ± 0.003 ml) (p<0.01).

Conclusions:

The proposed intravitreal injection technique effectively minimizes medication loss.
This novel method offers a practical and cost-effective alternative for intravitreal injections, reducing compound waste.