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Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.

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Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells
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Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells

Published on: July 14, 2023

Genetically engineered mesenchymal stem cells: The ongoing research for bone tissue engineering.

Dun Hong1, Hai-Xiao Chen, Renshan Ge

  • 1Institute of Cell Biology, Medical College of Zhejiang University, Hangzhou, China.

Anatomical Record (Hoboken, N.J. : 2007)
|December 23, 2009
PubMed
Summary
This summary is machine-generated.

Genetically engineered mesenchymal stem cells (MSCs) show promise for bone tissue engineering (BTE). Modifying MSCs can enhance bone formation and repair, overcoming limitations of current bone grafting techniques.

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Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
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10:30

Mesenchymal Stromal Cell Culture and Delivery in Autologous Conditions: A Smart Approach for Orthopedic Applications

Published on: December 8, 2016

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Orthopedic Surgery

Background:

  • Bone grafting is essential for treating bone defects and nonunion fractures.
  • Biomaterial scaffolds have limited osteogenic potential, necessitating cell-based approaches.
  • Mesenchymal stem cells (MSCs) are promising for bone tissue engineering (BTE), but controlling their differentiation is challenging.

Purpose of the Study:

  • To review the applications of genetically engineered MSCs in bone tissue engineering.
  • To discuss gene modification strategies, vector safety, and delivery methods for MSCs in BTE.
  • To explore in vivo tracking and clinical potential of genetically modified MSCs for bone regeneration.

Main Methods:

  • Literature review of studies involving genetically engineered MSCs for BTE.
  • Analysis of applicable genes and candidate genes for MSC modification.
  • Evaluation of transduction efficiency, vector safety, and administration routes.

Main Results:

  • Genetically engineered MSCs can be modified to enhance osteogenic differentiation and bone formation.
  • Various genes and delivery vectors are being explored to improve MSC efficacy and safety.
  • In vivo tracking and potential clinical applications are being investigated.

Conclusions:

  • Genetically engineered MSCs offer a promising strategy to improve bone regeneration in BTE.
  • Further research is needed to optimize gene modification, delivery, and clinical translation.
  • This approach holds potential for enhanced fracture repair and spinal fusion.