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Updated: Jun 17, 2026

Curcuminoid-Mediated Antimicrobial Photodynamic Therapy on a Murine Model of Oral Candidiasis

Curcuminoid-Mediated Antimicrobial Photodynamic Therapy on a Murine Model of Oral Candidiasis

Published on: October 27, 2023

Curcumin and its analogues: potential anticancer agents.

Dinesh Kumar Agrawal¹, Pushpesh Kumar Mishra

¹Agra Public Institute of Technology and Computer Education, Department of Pharmacy, Artoni, Agra, India. agrawaldka@gmail.com

Medicinal Research Reviews

|December 23, 2009

Summary

This summary is machine-generated.

Curcumin, a turmeric compound, and its synthetic analogs show significant anticancer potential by targeting multiple cell pathways. Some analogs exhibit potent activity, warranting further investigation as future cancer therapeutics.

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Last Updated: Jun 17, 2026

Curcuminoid-Mediated Antimicrobial Photodynamic Therapy on a Murine Model of Oral Candidiasis

Curcuminoid-Mediated Antimicrobial Photodynamic Therapy on a Murine Model of Oral Candidiasis

Published on: October 27, 2023

Area of Science:

Natural Products Chemistry
Medicinal Chemistry
Pharmacology

Background:

Curcumin, a phytochemical from Turmeric (Curcuma Longa), exhibits diverse biological activities.
It modulates key cell signaling pathways involved in cancer, including apoptosis, proliferation, angiogenesis, and inflammation.
Over the past century, significant research has focused on developing curcumin-based anticancer agents.

Purpose of the Study:

To review the development of curcumin analogues for anticancer activity.
To summarize the pharmacological activities of various synthetic curcumin derivatives.
To identify promising curcumin analogues for potential clinical development.

Main Methods:

Comprehensive literature review of curcumin analogues and their anticancer properties.
Analysis of studies evaluating synthetic curcumin derivatives in various cancer models and cell lines.
Compilation of data on pharmacological activities beyond anticancer effects.

Main Results:

Over 700 curcumin analogues have been synthesized and evaluated.
Many analogues demonstrate potent anticancer activity across different models.
Additional activities observed include antioxidant, anti-HIV, anti-inflammatory, and antiangiogenic effects.

Conclusions:

Curcumin analogues represent a promising class of compounds for cancer therapy.
Several analogues display potent efficacy and may be considered for clinical trials.
The broad spectrum of activities highlights the therapeutic versatility of curcumin derivatives.