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Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2 (COX-2),...
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
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Local Anesthetics: Common Agents and Their Applications01:23

Local Anesthetics: Common Agents and Their Applications

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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Updated: Jun 17, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Topical corticosteroids in dermatology.

Sujatha Tadicherla1, Kate Ross, Philip D Shenefelt

  • 1Department of Dermatology and Cutaneous Surgery, MDC 79, University of South Florida,Tampa, FL 33612, USA.

Journal of Drugs in Dermatology : JDD
|December 24, 2009
PubMed
Summary

Topical corticosteroids are widely used for skin conditions, offering versatile treatment options. Careful application and patient education are key to maximizing benefits and minimizing potential side effects.

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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging
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Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging

Published on: November 24, 2021

Area of Science:

  • Dermatology
  • Pharmacology

Background:

  • Topical corticosteroids are mainstays in dermatologic treatment.
  • Available in various strengths and vehicles for tailored therapy.

Purpose of the Study:

  • To review the use of topical corticosteroids in dermatology.
  • To highlight efficacy, formulation options, and side effect management.

Main Methods:

  • Literature review of topical corticosteroid applications.
  • Analysis of formulation vehicles and their impact on potency.

Main Results:

  • Corticosteroids are effective as monotherapy or combination treatment.
  • Formulation and vehicle choice influence efficacy and site-specific use.
  • Potential for local and systemic side effects exists.

Conclusions:

  • Judicious use of topical corticosteroids is crucial.
  • Patient education is vital for safe and effective dermatologic treatment.