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Efficacy of a lipid-based barrier repair formulation in moderate-to-severe pediatric atopic dermatitis

Jeffrey L Sugarman1, Lawrence Charles Parish

  • 1Department of Dermatology, University of California, San Francisco, CA, USA. pediderm@yahoo.com

Journal of Drugs in Dermatology : JDD
|December 24, 2009
PubMed

Insights

A ceramide-dominant lipid formulation (EpiCeram) effectively treated atopic dermatitis (AD) symptoms, including severity, itch, and sleep, comparable to a steroid cream by day 28.

Area of Science:

  • Dermatology
  • Biochemistry
  • Clinical Trials

Background:

  • Atopic dermatitis (AD) involves lipid-biochemical abnormalities.
  • Restoring the skin barrier is crucial for AD management.

Purpose of the Study:

  • To evaluate EpiCeram, a ceramide-dominant triple-lipid formulation, for atopic dermatitis (AD).
  • To compare EpiCeram's efficacy against fluticasone propionate cream in AD patients.

Main Methods:

  • A five-center, investigator-blinded, randomized trial involving 121 patients with moderate-to-severe AD.
  • Primary outcomes included SCORAD scores, pruritus reduction, and sleep habit improvement.
  • Comparison between EpiCeram and fluticasone cream over 28 days.

Main Results:

  • EpiCeram significantly reduced disease severity, pruritus, and improved sleep at 14 and 28 days.
  • While fluticasone showed faster initial improvement at 14 days, EpiCeram achieved comparable results by 28 days.
  • No significant difference in SCORAD, pruritus, or sleep scores between EpiCeram and fluticasone by day 28.

Conclusions:

  • Ceramide-dominant, physiological-lipid formulations like EpiCeram show promise for AD treatment.
  • EpiCeram may serve as an effective standalone or adjunctive therapy for pediatric AD.
  • This formulation offers a potential therapeutic option for managing atopic dermatitis.
Abstract

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