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Updated: Jun 17, 2026

In vitro Synthesis of Native, Fibrous Long Spacing and Segmental Long Spacing Collagen
Published on: September 20, 2012
Dissolving collagen fillers: enzymatic degradation of some problematic filler circumstances may now include collagens
William D Tutrone1, Joel L Cohen
1University of Alabama in Procedural Dermatology, Birmingham, AL, USA. Wil.tutrone@gmail.com
Abstract:
The market for non-permanent fillers has grown dramatically over the past years. Even though hyaluronic acid fillers and collagen are forgiving, complications, albeit rare, still occur. Up to now, a necessary element of any dermatologic surgeons' office is a hyaluronidase in case one of these complications should occur. However, these agents will only work on hyaluronic acid fillers leaving any problem with collagen products to be resolved by other means. Later this year the first collagenase could be approved for usage in specific medical conditions; at that time it will, perhaps, complement its hyaluronidase counterpart.
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