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Updated: Jun 17, 2026

A Planarian Motility Assay to Gauge the Biomodulating Properties of Natural Products
Published on: May 30, 2020
Neocomplanines A and B, a complanine family isolated from the marine fireworm
Kazuhiko Nakamura1, Yu Tachikawa, Osamu Ohno
1Department of Biosciences and Informatics, Keio University, 3-14-1 Hiyoshi, Yokohama 223-8522, Japan.
Abstract:
Two new members of the complanine family, neocomplanines A (2) and B (3), were isolated as minor components of the methanolic extract of the "marine fireworm" Eurythoe complanata. The structures of the neocomplanines were revealed spectroscopically to be a trimethylammonium unit with a saturated carbon chain. The planar structures of neocomplanines A and B were confirmed successfully through total syntheses that used epichlorohydrin as a starting material. The neocomplanines show inflammatory activity and also enhanced PKC activity in combination with TPA in the presence of Ca(2+) in vitro; both are similar to the effects of complanine (1). The molecular mechanism of the effects of complanine-related compounds is discussed.
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