Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Cerebral oxygenation response to postural change using continuous near-infrared spectroscopy (NIRS) and its association with falls in older adults.

European geriatric medicine·2026

Same author

Beat-to-Beat Blood Pressure Monitoring and Orthostatic Hypotension-Related Falls in Two Cohorts of Older Adults.

Geriatrics (Basel, Switzerland)·2025

Same author

The impact of clot permeability on platelet fluxes toward its surface.

PloS one·2025

Same author

Cascades Towards Noise-Induced Transitions on Networks Revealed Using Information Flows.

Entropy (Basel, Switzerland)·2025

Same author

Carotid single- and dual-layer stents reduce the wall adhesion of platelets by influencing flow and cellular transport.

Computers in biology and medicine·2024

Same author

The effect of flow-derived mechanical cues on the growth and morphology of platelet aggregates under low, medium, and high shear rates.

Computers in biology and medicine·2024

Same journal

Literature-informed gene extraction and ranking for multimodal data fusion.

Briefings in bioinformatics·2026

Same journal

SA-MTP: a structure-aware framework for multifunctional therapeutic peptide annotation.

Briefings in bioinformatics·2026

Same journal

Genome assemblies and annotations are not static and need support for tracking their evolution.

Briefings in bioinformatics·2026

Same journal

A historical journey of metabolite-protein interaction discovery: from data harmonization to AI-driven prediction.

Briefings in bioinformatics·2026

Same journal

Bridging local-global transmembrane protein contexts with contrastive pretraining for alignment-free pathogenicity prediction.

Briefings in bioinformatics·2026

Same journal

Prediction of drug hypersensitivity by comprehensive modeling of HLA-peptidomes.

Briefings in bioinformatics·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 17, 2026

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance

Published on: February 13, 2026

Multi-scale modelling in computational biomedicine.

Peter M A Sloot¹, Alfons G Hoekstra

¹Computational Science, Faculty of Science, University of Amsterdam, Kruislaan 403, 1098 SJ Amsterdam, The Netherlands. p.m.a.sloot@uva.nl

Briefings in Bioinformatics

|December 24, 2009

Summary

This summary is machine-generated.

Computational biomedicine uses multi-scale modeling to understand complex biological systems. This review proposes a unified methodology for these models, illustrated with HIV resistance and in-stent restenosis case studies.

More Related Videos

Scaled Anatomical Model Creation of Biomedical Tomographic Imaging Data and Associated Labels for Subsequent Sub-surface Laser Engraving (SSLE) of Glass Crystals

Scaled Anatomical Model Creation of Biomedical Tomographic Imaging Data and Associated Labels for Subsequent Sub-surface Laser Engraving (SSLE) of Glass Crystals

Published on: April 25, 2017

In Silico Clinical Trials for Cardiovascular Disease

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

Related Experiment Videos

Last Updated: Jun 17, 2026

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance

Published on: February 13, 2026

Scaled Anatomical Model Creation of Biomedical Tomographic Imaging Data and Associated Labels for Subsequent Sub-surface Laser Engraving (SSLE) of Glass Crystals

Scaled Anatomical Model Creation of Biomedical Tomographic Imaging Data and Associated Labels for Subsequent Sub-surface Laser Engraving (SSLE) of Glass Crystals

Published on: April 25, 2017

In Silico Clinical Trials for Cardiovascular Disease

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

Area of Science:

Computational biomedicine
Systems biology
Mathematical modeling

Background:

Biomedical systems are inherently complex, operating across multiple temporal and spatial scales.
Existing multi-scale models often lack a unified methodological framework.
The integration of diverse scientific disciplines is crucial for comprehensive biomedical understanding.

Purpose of the Study:

To review the emerging field of multi-scale modeling in computational biomedicine.
To propose a unifying methodological direction for multi-scale modeling.
To illustrate the proposed approach with relevant biomedical case studies.

Main Methods:

Review of current multi-scale modeling approaches in computational biomedicine.
Proposal of a novel methodological direction complementing dynamical systems.
Application of the methodology to two distinct case studies: HIV resistance and in-stent restenosis.

Main Results:

Identification of a gap in underpinning methodologies for multi-scale biomedical models.
Demonstration of a viable direction for developing a unified multi-scale modeling framework.
Successful application of the proposed framework to analyze complex disease dynamics.

Conclusions:

A unified methodology is needed to advance multi-scale modeling in computational biomedicine.
The proposed direction offers a promising approach to integrate diverse models and scales.
Multi-scale modeling holds significant potential for understanding and treating complex diseases like HIV and coronary artery disease.