Related Experiment Video
Updated: Jun 17, 2026
06:01
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
Relationship between cerebral hypoxic tissue volume and prognosis after stroke
Yi-Dong Wang1, Xiang-Pen Li, Mei Li
1Department of Neurology, Second Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China. wydys@yahoo.com.cn
European Neurology
|December 24, 2009
Summary
Assessing hypoxic tissue volume within 14 days after stroke can predict patient recovery. Hypoxia-positive patients showed significant improvement, indicating its value for stroke prognosis.
Area of Science:
- Neurology
- Medical Imaging
- Stroke Research
Background:
- Stroke survivors frequently experience severe disabilities like paralysis and aphasia.
- Incomplete understanding of stroke mechanisms hinders effective treatment development.
- This study investigates the link between hypoxic tissue and stroke patient outcomes.
Purpose of the Study:
- To evaluate the significance of hypoxic tissue volume in predicting stroke patient prognosis.
- To correlate hypoxic tissue presence with patient recovery and long-term outcomes.
Main Methods:
- Quantified hypoxic tissue volume within 14 days post-stroke.
- Classified patients into hypoxic positive or negative groups.
- Assessed patient condition at imaging, 21 days, 30 days, and 90 days post-stroke.
Main Results:
- Hypoxia-positive patients demonstrated significant improvement compared to hypoxia-negative patients.
- A positive correlation was found between hypoxic tissue volume and 90-day recovery scores.
- Early detection of hypoxic tissue (within 14 days) predicted 3-week recovery and 90-day prognosis.
Conclusions:
- Assessing hypoxic tissue volume post-stroke is a valuable tool for predicting patient recovery.
- This imaging biomarker may aid in tailoring stroke treatment strategies.
Related Concept Videos
01:15Ischemic Stroke ll: Pathophysiology
An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
01:15Ischemic Stroke l: Introduction
Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
01:27Regulation of Stroke Volume
The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
01:29Hemorrhagic Stroke ll: Pathophysiology
A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
01:22Cardiac Output II: Effect of Stroke Volume on Cardiac Output
Cardiac output (CO), the amount of blood the heart pumps per minute, is a parameter in cardiovascular physiology determined by stroke volume and heart rate. Stroke volume, the amount of blood pushed from one of the ventricles per heartbeat, is influenced by preload, afterload, and contractility.
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...
01:17Hemorrhagic Stroke l: Introduction
A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...