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Synchronous Triplanar Reconstruction Integrated with Color Doppler Mapping for Precise and Rapid Localization of Thyroid Lesions
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Calcification-related absorption in thyroid scintigraphy.

E G Eising1, W Jentzen

  • 1Clinic and Policlinic for Nuclear Medicine, University of Duisburg/Essen, Germany. e-g-e@web.de

Nuklearmedizin. Nuclear Medicine
|December 24, 2009
PubMed
Summary
This summary is machine-generated.

Calcifications in the sternal bone or thyroid nodules can rarely cause visible absorption effects, potentially reducing uptake in thyroid scintigraphy. These effects should be considered during interpretation.

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Area of Science:

  • Nuclear medicine
  • Radiology
  • Medical imaging

Background:

  • Conventional radiography relies on X-ray absorption by calcified bone.
  • Absorption effects of calcifications in thyroid nodules or sternal bone on scintigraphy are not well-documented.
  • High energy of technetium-99m (99mTc) photons (140 keV) was thought to make absorption effects unlikely.

Purpose of the Study:

  • To experimentally investigate potential absorption effects of calcifications on thyroid scintigraphy.
  • To evaluate the impact of sternal bone and thyroid calcifications on imaging.
  • To determine if calcifications influence the visibility of uptake in thyroid scans.

Main Methods:

  • Tested calcium absorbers on a technetium flood phantom.
  • Simulated absorption effects using calcium sulphate and carbonate discs in a thyroid phantom.
  • Analyzed CT scans of 46 patients for sternal bone and thyroid calcifications, and correlated with phantom studies.

Main Results:

  • CT identified sternal bone or thyroid calcifications in 24/46 patients (mean density 219 HU).
  • Quantitative measurements showed a mean 99mTc absorption of 4.9% by calcifications.
  • Absorption effects were visible in phantom studies, particularly with moderate surrounding tissue uptake; no dependence on calcification chemistry was found.

Conclusions:

  • Visible absorption effects from sternal bone or thyroid calcifications are infrequent.
  • These effects can potentially reduce visible uptake in thyroid scintigraphy.
  • Consideration of calcifications is important for accurate interpretation of thyroid scintigrams.