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A computer case definition for sudden cardiac death.

Cecilia P Chung1, Katherine T Murray, C Michael Stein

  • 1Division of Rheumatology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.

Pharmacoepidemiology and Drug Safety
|December 24, 2009
PubMed
Summary
This summary is machine-generated.

A new computer definition accurately identifies sudden cardiac death (SCD) in Medicaid enrollees. This tool aids medication studies by reliably detecting SCD using linked health and death records.

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Published on: December 28, 2012

Area of Science:

  • Cardiology
  • Public Health
  • Health Informatics

Background:

  • Sudden cardiac death (SCD) is a critical public health concern.
  • Accurate identification of SCD is essential for epidemiological studies, particularly those investigating medication effects.
  • Existing methods for identifying SCD in large populations can be labor-intensive and may lack precision.

Purpose of the Study:

  • To develop and validate a computerized case definition for sudden cardiac death (SCD).
  • To facilitate research on medications and their potential association with SCD.
  • To create a reliable tool for identifying SCD within a Medicaid population.

Main Methods:

  • A retrospective cohort study was conducted using linked databases: Medicaid inpatient/outpatient files, state death certificates, and a state all-payers hospital discharge file.
  • A computerized case definition was developed based on criteria including absence of terminal hospital/nursing home stay, appropriate cause of death code, and lack of inconsistent terminal procedures.
  • The definition was validated on an independent dataset of adjudicated sudden cardiac deaths.

Main Results:

  • The developed computer case definition demonstrated a positive predictive value of 86.0% in the initial development sample.
  • Validation in an independent sample yielded a positive predictive value of 86.8%.
  • The accuracy remained consistent across different coding systems (ICD-9 and ICD-10).

Conclusions:

  • A linked database combining Medicaid records, death certificates, and hospital discharge data can effectively support a computerized case definition for sudden cardiac death.
  • This validated tool offers a reliable method for identifying SCD in large populations.
  • The approach is suitable for epidemiological research, including studies on medication safety and SCD risk.