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Updated: Jun 17, 2026

Synthesis and Purification of Iodoaziridines Involving Quantitative Selection of the Optimal Stationary Phase for Chromatography
Published on: May 16, 2014
Enantioseparation of benzazoles and benzanilides on polysaccharide-based chiral columns
Takateru Kubota1, Naotaka Sawada, Lili Zhou
1Department of Process Research, Merck Research Laboratories, Merck & Co., Inc, Tsukuba, Ibaraki 300-2611, Japan. Takateru_kubota@merck.com
Abstract:
The chiral recognition ability of the polysaccharide-based chiral columns (Chiralpak AD-RH, Chiralpak AS-RJ, Chiralpak IC, Chiralcel OD-RH, and Chiralcel OJ-RH) for the benzazoles and the benzanilides was evaluated under reversed phase conditions. The columns showed the high chiral recognition ability for a wide range of benzazoles and benzanilides. Twenty-one racemates were used for the evaluation, and 20 racemates were completely separated on at least one of the columns. In particular, AS-RH and OJ-RH showed the high chiral recognition ability for the benzazoles, and the AD-RH, IC, and OJ-RH were effective for the benzanilides.
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