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Updated: Jun 17, 2026
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Published on: April 17, 2012
Role of radiotherapy in early glottic carcinoma
Robert I Smee1, Nicola S Meagher, Janet R Williams
1Department of Radiation Oncology, The Prince of Wales Cancer Centre, High Street, Randwick, New South Wales 2031, Australia. robert.smee@sesiahs.health.nsw.gov.au
Background:
Early glottic carcinoma has a high local control prospect with radiotherapy. This review evaluates a single center's experience.
Methods:
All patients from 1967 to 2006 diagnosed with Tis/T1/T2/N0 early glottic carcinoma treated definitively with radiotherapy at Prince of Wales Hospital were reviewed. Local control and cancer-specific survival (CSS) rates were primary endpoints, and the impact of various factors on these outcomes was statistically analyzed.
Results:
This review of 522 patients includes 24 with Tis, 356 with T1, and 142 with T2. Ultimate local control rates were as follows: Tis 87.5%, T1 94.7%, and T2 84.5%. Multivariate analysis found fitness for surgery, no involvement of anterior commissure, normal cord movement, and radiotherapy dose >60 Gy significant for local control. Fitness for surgery, no involvement of the anterior commissure, normal cord movement, and no ventricular involvement were significant prognostic factors for CSS.
Conclusion:
Definitive radiotherapy for early glottic carcinoma provides high local control rates, with the option of surgical salvage to achieve ultimate local control.
