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Updated: Jun 17, 2026
Synthesis and Characterization of Placental Chondroitin Sulfate A (plCSA)-Targeting Lipid-Polymer Nanoparticles
Published on: September 18, 2018
[Preparation and in vitro evaluation of brucine-loaded polylacticacid nanoparticles]
Jihui Zhao1, Zhaolin Liu, Jie Xu
1Department of Pharmaceutics, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Objective:
To prepare and evaluate brucine-loaded polylacticacid nanoparticles (Bru-PLA-NPs).
Method:
The Bru-PLA-NPs were prepared by solvent diffusion method. The physical, chemical properties and in vitro release behavior of the prepared Bru-PLA-NPs were evaluated, respectively.
Result:
The mean particle size of the prepared Bru-PLA-NPs was 95 nm with polydispersity index of 0.362. The zeta potential was -15.68 mV. The mean loading and entrapment efficiency of Bru were 7% and 37%, respectively. Compared with Bru solution, an obvious sustained release behavior of Bru from Bru-PLA-NPs was observed in the in vitro release experiment.
Conclusion:
The Bru-PLA-NPs prepared by solvent diffusion method exhibit small particle size, high Bru-loading efficiency, and obvious sustained release in vitro
