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Updated: Jun 17, 2026
Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations
Published on: October 20, 2017
[Treatment of complicated cavernous venous malformation with retained copper wires combined with pingyangmycin
Si-Ming Yuan1, Hui-Qing Jiang, Zhi-Jian Hong
1Department of Plastic and Burn Surgery, Nanjing General Hospital of Nanjing Military Command, PLA, Nanjing 210002, China.
Objective:
To evaluate the therapeutic effect of retained copper wires combined with pingyangmycin (PYM) injection for complicated cavernous venous malformation.
Methods:
The location of venous malformation was detected by physical examination and MRI. The copper wires in 0.2 mm width were used to puncture the lesion repeatedly and retained in the lesion to form a net. After that, 8 mg PYM was injected into the residue malformed veins. 8-10 days later, the copper wires were taken out and necrotic tissue was squeezed out. The wounds of punctual holes healed through dressing. The patients received postoperative MRI to evaluate the therapeutic effect.
Results:
From Jan. 2002 to Dec. 2008, 45 cases were treated. The patients were followed up for 1-3 years. 51.1% (23/45) of the lesions shrinked markedly or even disappeared. 42.2% (19/45) of the lesions reduced. 6.67% (3/45) of the lesions didn't change. There was no complication like invasive infection.
Conclusions:
It is very effective to treat complicated cavernous venous malformation with retained copper wires combined with pingyangmycin injection.
Insights
Retained copper wires and pingyangmycin injection effectively treat complicated cavernous venous malformations. This minimally invasive approach led to significant lesion reduction or disappearance in most patients without complications.
Area of Science:
- Vascular Surgery
- Interventional Radiology
- Dermatology
Background:
- Complicated cavernous venous malformations present significant therapeutic challenges.
- Existing treatments may have limitations in efficacy or invasiveness.
Purpose of the Study:
- To evaluate the therapeutic efficacy of a combined approach using retained copper wires and pingyangmycin (PYM) injection for complicated cavernous venous malformations.
Main Methods:
- Physical examination and MRI were used for lesion detection.
- Copper wires were inserted to create a net within the malformation, followed by PYM injection.
- Post-procedure MRI assessed therapeutic outcomes, with wires removed after 8-10 days.
Main Results:
- 51.1% of patients showed marked shrinkage or disappearance of lesions.
- 42.2% experienced lesion reduction; only 6.67% showed no change.
- No invasive infections or other complications were reported during follow-up.
Conclusions:
- The combination of retained copper wires and pingyangmycin injection is a highly effective treatment for complicated cavernous venous malformations.
- This method offers a safe and minimally invasive therapeutic option with favorable outcomes.
