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Related Experiment Video

Updated: Jun 17, 2026

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model
09:42

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model

Published on: June 4, 2021

[Transcranial sonothrombolysis].

Hiroshi Furuhata1

  • 1ME Lab. Research Center for Medical Science, The Jikei University School of Medicine.

Rinsho Shinkeigaku = Clinical Neurology
|December 25, 2009
PubMed
Summary

Low frequency ultrasound enhances tissue plasminogen activator for acute ischemic stroke. A new system, transcranial targeting Low Frequency Ultrasonic Thrombolysis (TCT-LoFUT), aims for early recanalization.

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Area of Science:

  • Biomedical Engineering
  • Neurology
  • Medical Imaging

Context:

  • Intravenous recombinant tissue plasminogen activator (IVrt-PA) is a standard treatment for acute ischemic stroke.
  • Transcranial ultrasonic diagnostic equipment is approved to augment IVrt-PA's thrombolytic efficacy.
  • Low frequency ultrasound shows significant advantages in enhancing IVrt-PA's lytic effect.

Purpose:

  • To optimize ultrasonic conditions for transcranial sonothrombolysis.
  • To develop a novel transcranial targeting Low Frequency Ultrasonic Thrombolysis (TCT-LoFUT) system.

Summary:

  • The TCT-LoFUT system is designed to target low frequency ultrasound for thrombolysis.
  • This system aims to improve the effectiveness of IVrt-PA in breaking down blood clots.
  • The development focuses on achieving optimal ultrasonic parameters for enhanced therapeutic outcomes.

Impact:

  • The TCT-LoFUT system is anticipated to be a valuable therapeutic tool.
  • It holds the potential to facilitate early recanalization in acute ischemic stroke patients.
  • This technology could significantly improve treatment outcomes and reduce long-term disability.

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