Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

1.0K
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
1.0K
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

1.9K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
1.9K
Gene Therapy00:59

Gene Therapy

27.4K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.4K
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

663
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
663
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.6K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.6K
Group Therapy01:26

Group Therapy

403
Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
403

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

AAV-based gene therapy with modified HEXB confers lasting therapeutic benefits in GM2 gangliosidosis models.

Cell reports. Medicine·2026
Same author

An Analysis of Biomarkers for the Evaluation of Gene Therapy in Niemann-Pick Disease Type C1 Mice.

Human gene therapy·2026
Same author

Correction: Machine learning model for predicting the cold-heat pattern in Kampo medicine: a multicenter prospective observational study.

Frontiers in pharmacology·2026
Same author

Less Invasive Light Irradiation Methods for Inner Ear Gene Therapy Based on Photoswitch Technology: Toward Clinical Translation.

Human gene therapy·2026
Same author

Teneurin-4 in the nucleus accumbens modulates affective-like behaviors with potential effects on astrocytes in male mice.

Biochemical and biophysical research communications·2026
Same author

Spinal Shati/nat8l regulates mechanical hyperalgesia through NAAG-mGluR3 signaling in neuropathic pain.

Neuropharmacology·2026

Related Experiment Video

Updated: Jan 25, 2026

Author Spotlight: Exploring Non-Motor Symptoms in Parkinson's Disease
03:20

Author Spotlight: Exploring Non-Motor Symptoms in Parkinson's Disease

Published on: September 22, 2023

2.3K

[Cell therapy for Parkinson disease].

Shin-ichi Muramatsu1

  • 1Division of Neurology, Jichi Medical University.

Rinsho Shinkeigaku = Clinical Neurology
|December 25, 2009
PubMed
Summary

Stem cell therapies show promise for Parkinson disease (PD) by replacing lost neurons. However, challenges like tumor risk and graft survival must be addressed for safe and effective human treatments.

Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Stem Cell Biology

Context:

  • Parkinson disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons.
  • Current cell replacement therapies for PD face challenges including controversial clinical trial outcomes and pathological changes in grafted cells.
  • Stem cell-derived dopaminergic neurons show promise in preclinical models of PD.

Purpose:

  • To review the current state and future directions of stem cell-based therapies for Parkinson disease.
  • To identify key obstacles hindering the clinical application of stem cell therapy for PD.
  • To explore alternative and complementary strategies for treating PD.

Summary:

  • Dopaminergic neurons can be efficiently generated from stem cells, demonstrating therapeutic potential in animal models of PD.

More Related Videos

Author Spotlight: Establishing a New Fluorescence-Based Protocol for In Vivo Mitochondrial Morphology Analysis in Parkinson's Disease
06:07

Author Spotlight: Establishing a New Fluorescence-Based Protocol for In Vivo Mitochondrial Morphology Analysis in Parkinson's Disease

Published on: June 23, 2023

2.2K
Ole Isacson: Development of New Therapies for Parkinson's Disease
23:53

Ole Isacson: Development of New Therapies for Parkinson's Disease

Published on: April 28, 2007

8.4K

Related Experiment Videos

Last Updated: Jan 25, 2026

Author Spotlight: Exploring Non-Motor Symptoms in Parkinson's Disease
03:20

Author Spotlight: Exploring Non-Motor Symptoms in Parkinson's Disease

Published on: September 22, 2023

2.3K
Author Spotlight: Establishing a New Fluorescence-Based Protocol for In Vivo Mitochondrial Morphology Analysis in Parkinson's Disease
06:07

Author Spotlight: Establishing a New Fluorescence-Based Protocol for In Vivo Mitochondrial Morphology Analysis in Parkinson's Disease

Published on: June 23, 2023

2.2K
Ole Isacson: Development of New Therapies for Parkinson's Disease
23:53

Ole Isacson: Development of New Therapies for Parkinson's Disease

Published on: April 28, 2007

8.4K
  • Clinical application requires addressing safety concerns such as tumor formation, potentially through prodrug/suicide gene therapy.
  • Grafting strategies and the functional recovery mechanisms (e.g., dopaminergic neurotransmission restoration) are critical considerations.
  • Alternative approaches like viral vector-mediated gene delivery of dopamine-synthesizing enzymes offer a more direct therapeutic route.

    • Impact:

    • Advances in stem cell technology offer new avenues for Parkinson disease treatment development.
    • Overcoming current limitations could lead to safer and more effective cell-based therapies for PD patients.
    • Future research may expand cell therapy targets to include conditions involving striatal neuron degeneration.