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Updated: Jun 17, 2026

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
Published on: March 2, 2014
[Human caliciviruses and an immune response].
Calicivirus infections, known in animals, are now recognized in humans, causing widespread gastroenteritis outbreaks. This review covers their history, evolution, and the host immune response to these viruses.
Area of Science:
- Virology
- Immunology
- Epidemiology
Context:
- Calicivirus infections have been historically documented in animal populations.
- Recent findings confirm the emergence and impact of caliciviruses in human health.
- Human caliciviruses are a significant cause of acute gastroenteritis globally.
Purpose:
- To provide a comprehensive overview of calicivirus infections.
- To detail the history and evolution of caliciviruses.
- To explore host resistance and immune response mechanisms against caliciviruses.
Summary:
- This review examines the discovery and evolution of caliciviruses.
- It details the mechanisms of host resistance and immune responses to calicivirus infection.
- The global impact of human calicivirus-induced gastroenteritis outbreaks is highlighted.
Impact:
- Enhances understanding of viral gastroenteritis pathogenesis.
- Informs public health strategies for controlling viral outbreaks.
- Provides a foundation for developing targeted antiviral therapies and vaccines.
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