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Related Concept Videos

Ligand Binding Sites02:40

Ligand Binding Sites

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Updated: Jun 17, 2026

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Switchable wettability on cooperative dual-responsive poly-L-lysine surface.

Yi Guo1, Fan Xia, Li Xu

  • 1Key Laboratory of Surface and Interface Chemistry of Jilin Province, College of Chemistry, Jilin University, Changchun 130012, PR China.

Langmuir : the ACS Journal of Surfaces and Colloids
|December 25, 2009
PubMed
Summary

A novel polypeptide surface switches between superhydrophilic and superhydrophobic states using pH and temperature stimuli. This smart material surface offers potential applications in nanodevices and biosensors.

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Area of Science:

  • Materials Science
  • Surface Chemistry
  • Polymer Science

Background:

  • Developing smart materials with tunable surface properties is crucial for advanced applications.
  • Polypeptides offer versatile building blocks for responsive materials.

Purpose of the Study:

  • To present a cooperative dual-responsive polypeptide surface.
  • To investigate the switching mechanism between superhydrophilic and superhydrophobic states.
  • To explore the potential applications of this smart surface.

Main Methods:

  • Immobilizing poly-L-lysine (PLL) on a substrate to create a micro/nanocomposite structure.
  • Utilizing pH and temperature as stimuli to induce conformational changes in PLL.
  • Observing surface state transitions using macroscopic phenomena.

Main Results:

  • The polypeptide surface exhibits reversible switching between superhydrophilic and superhydrophobic states.
  • Surface states are controlled by pH- and temperature-induced unfolding and aggregation of PLL.
  • The material demonstrates a "memory" effect for its hydrophobicity and hydrophilicity.

Conclusions:

  • A cooperative dual-responsive polypeptide surface was successfully developed.
  • The surface switching mechanism is linked to PLL conformation changes (random coil, alpha-helix, beta-sheet).
  • This research opens prospects for smart material design in nanodevices, bioseparation, and biosensors.