Related Experiment Video
Updated: Jun 17, 2026

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
Published on: November 2, 2016
Synthesis and leishmanicidal activity of 2,3,4-substituted-5-imidazolones
Khalid Mohammed Khan1, Uzma Rasool Mughal, Nida Ambreen
1H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan. hassaan2@super.net.pk
Abstract:
Twenty-nine imidazolones 1-29 were synthesized and were randomly screened for their in vitro anti-leishmanial potential. Compound 17 showed a good anti-leishmanial activity with an IC50 value of 12.98 +/- 0.32 microg/mL. Compounds 14 and 24 were also found to be moderately active (IC50 values 28.20 +/- 0.03 and 41.12 +/- 0.32 microg/mL, respectively). The activity was compared with that of standard drugs, amphotericin B (IC50 = 0.12 +/- 0.41 microg/mL) and pentamidine (IC50 = 2.56 +/- 0.10 microg/mL).
More Related Videos
08:48Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
Published on: January 26, 2016
10:01Quantification of Intracellular Growth Inside Macrophages is a Fast and Reliable Method for Assessing the Virulence of Leishmania Parasites
Published on: March 16, 2018
Related Concept Videos
Antiprotozoal Agents
Leishmaniasis
Anthelminthic Agents
Antiviral Nucleoside Inhibitors
Diazonium Group Substitution with Halogens and Cyanide: Sandmeyer and Schiemann Reactions
Diazonium Group Substitution: –OH and –H