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[Individualizing treatment of refractory and relapsed ITP in adults and its development of study]

Yu Huang1, Wei Li, Bo Yang

  • 1Department of Geriatric Hematology, Chinese PLA General Hospital, Beijing 100853, China; Tumor Center of the First Hospital of Jilin University, Changchun 130021, Jilin Province, China.

Zhongguo Shi Yan Xue Ye Xue Za Zhi
|December 25, 2009
PubMed

Idiopathic thrombocytopenic purpura (ITP) is a common hematological disease. It bleeds with peripheral blood platelet reduction as the main clinical manifestation, and manifests a chronic history in adult people. 11% - 35% ITP patients develop into a refractory course, which may be related with gene polymorphisms. There is currently no consensus on how best to manage refractory/relapsed ITP. In part, this reflects the need for individualized treatment due to the patients' requirements and their responsiveness to therapies. The objective of this review is to provide a clinically useful guide to current management strategies. This article summarizes all the treatment for refractory ITP, and highlights new therapies, including the anti-CD20 antibody, thrombopoietic agents, TPO receptor agonist and HSCT. The pancytoprotector shows good effect in the treatment of refractory and relapsed ITP in China. In a word, to give different treatments individually is most important.

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