Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanistic Models: Compartment Models in Individual and Population Analysis01:23

Mechanistic Models: Compartment Models in Individual and Population Analysis

Mechanistic models are utilized in individual analysis using single-source data, but imperfections arise due to data collection errors, preventing perfect prediction of observed data. The mathematical equation involves known values (Xi), observed concentrations (Ci), measurement errors (εi), model parameters (ϕj), and the related function (ƒi) for i number of values. Different least-squares metrics quantify differences between predicted and observed values. The ordinary least squares (OLS)...
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
On...
Friedman Two-way Analysis of Variance by Ranks01:21

Friedman Two-way Analysis of Variance by Ranks

Friedman's Two-Way Analysis of Variance by Ranks is a nonparametric test designed to identify differences across multiple test attempts when traditional assumptions of normality and equal variances do not apply. Unlike conventional ANOVA, which requires normally distributed data with equal variances, Friedman's test is ideal for ordinal or non-normally distributed data, making it particularly useful for analyzing dependent samples, such as matched subjects over time or repeated measures from...
Analysis Methods of Pharmacokinetic Data: Model and Model-Independent Approaches01:14

Analysis Methods of Pharmacokinetic Data: Model and Model-Independent Approaches

Drug disposition in the body is a complex process and can be studied using two major approaches: the model and the model-independent approaches.
The model approach uses mathematical models to describe changes in drug concentration over time. Pharmacokinetic models help characterize drug behavior in patients, predict drug concentration in the body fluids, calculate optimum dosage regimens, and evaluate the risk of toxicity. However, ensuring that the model fits the experimental data accurately...
Noncompartmental Analysis: Statistical Moment Theory00:56

Noncompartmental Analysis: Statistical Moment Theory

Noncompartmental analyses leverage statistical moment theory to examine time-related changes in macroscopic events, encapsulating the collective outcomes stemming from the constituent elements in play. Statistical moment theory is a mathematical approach used to describe the time course of drug concentration in the body without assuming a specific compartmental model. SMT provides insights into drug absorption, distribution, metabolism, and elimination by treating drug concentration versus time...
Model Approaches for Pharmacokinetic Data: Distributed Parameter Models01:06

Model Approaches for Pharmacokinetic Data: Distributed Parameter Models

Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A new species of Laubuka (Cypriniformes: Danionidae) from the Sittaung River drainage, Myanmar.

Journal of fish biology·2026
Same author

A review of genus Laubuka (Cypriniformes: Danionidae) in Myanmar with description of two new species.

Zootaxa·2025
Same author

Development and validation of predictive models for distant metastasis and prognosis of gastroenteropancreatic neuroendocrine neoplasms.

Scientific reports·2025
Same author

The complex relationship between gut microbiota and Alzheimer's disease: A systematic review.

Ageing research reviews·2024
Same author

Molecular characteristics and systemic treatment options of liposarcoma: A systematic review.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2024
Same author

Soybean steroids improve crop abiotic stress tolerance and increase yield.

Plant biotechnology journal·2024

Related Experiment Video

Updated: Jun 17, 2026

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach
04:35

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach

Published on: July 3, 2020

Bayesian analysis of mixtures in structural equation models with non-ignorable missing data.

Jing-Heng Cai1, Xin-Yuan Song

  • 1Department of Statistics, Sun Yat-Sen University, Guangzhou, People's Republic of China.

The British Journal of Mathematical and Statistical Psychology
|December 25, 2009
PubMed
Summary

This study introduces a Bayesian approach for analyzing mixture structural equation models (SEMs) with unknown components and non-ignorable missing data. The method accurately estimates parameters and identifies model characteristics, offering a robust solution for complex data.

More Related Videos

Using Cholesky Decomposition to Explore Individual Differences in Longitudinal Relations between Reading Skills
06:52

Using Cholesky Decomposition to Explore Individual Differences in Longitudinal Relations between Reading Skills

Published on: September 17, 2019

The Innovation Arena: A Method for Comparing Innovative Problem-Solving Across Groups
14:14

The Innovation Arena: A Method for Comparing Innovative Problem-Solving Across Groups

Published on: May 13, 2022

Related Experiment Videos

Last Updated: Jun 17, 2026

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach
04:35

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach

Published on: July 3, 2020

Using Cholesky Decomposition to Explore Individual Differences in Longitudinal Relations between Reading Skills
06:52

Using Cholesky Decomposition to Explore Individual Differences in Longitudinal Relations between Reading Skills

Published on: September 17, 2019

The Innovation Arena: A Method for Comparing Innovative Problem-Solving Across Groups
14:14

The Innovation Arena: A Method for Comparing Innovative Problem-Solving Across Groups

Published on: May 13, 2022

Area of Science:

  • Social and Behavioral Sciences
  • Psychometrics
  • Statistical Modeling

Background:

  • Structural Equation Models (SEMs) are crucial for analyzing latent and observed variables in social sciences.
  • Mixture SEMs are essential for heterogeneous data, but analyzing them with non-ignorable missing data remains challenging.
  • Existing research on mixture SEMs with non-ignorable missing data is limited.

Purpose of the Study:

  • To develop a Bayesian approach for analyzing mixture SEMs with an unknown number of components and non-ignorable missing data.
  • To provide a flexible and robust methodology for complex statistical modeling in social sciences.
  • To address limitations in current methods for handling missing data in mixture SEMs.

Main Methods:

  • Development of a Bayesian framework utilizing Markov chain Monte Carlo (MCMC) methods.
  • Implementation of path sampling for Bayes factor computation.
  • Application to a real-world job satisfaction dataset.

Main Results:

  • Bayesian estimates derived from MCMC methods demonstrated high accuracy.
  • The Bayes factor proved effective in determining the correct number of components.
  • The methodology successfully identified appropriate missingness mechanisms and investigated latent variable effects.

Conclusions:

  • The proposed Bayesian approach offers a powerful tool for analyzing mixture SEMs with non-ignorable missing data.
  • The method facilitates accurate parameter estimation and model selection.
  • This research advances the statistical analysis of complex data structures in the social and behavioral sciences.