Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
Yellow Fever01:18

Yellow Fever

Yellow fever is a viral hemorrhagic disease caused by the yellow fever virus (YFV), a member of the Flaviviridae family. It is transmitted primarily by Aedes and Haemagogus mosquitoes in tropical and subtropical regions of Africa and South America. After transmission through a mosquito bite, the virus initially replicates in skin-resident immune cells such as dendritic cells and macrophages. These cells then migrate to the lymph nodes, where viral replication increases, eventually leading to...
Investigation of Disease Outbreaks01:23

Investigation of Disease Outbreaks

Multistate foodborne outbreaks pose significant public health risks and require meticulous investigation to identify sources and implement control measures. The Centers for Disease Control and Prevention (CDC) utilizes a dynamic seven-step process for these investigations, integrating data from laboratories, interviews, and environmental assessments to protect public health.Outbreak Detection: The detection of multistate outbreaks typically begins with PulseNet, the CDC's national laboratory...
Infectious Diseases and Their Occurrence01:28

Infectious Diseases and Their Occurrence

Infectious diseases appear in populations through various transmission patterns, influenced by pathogen characteristics, population immunity, environmental conditions, and social behavior. Understanding these patterns is essential for effective public health surveillance and intervention. These categories—sporadic, outbreak, epidemic, pandemic, and endemic—help frame the nature and scope of disease events.Sporadic diseases occur irregularly and infrequently, without a predictable temporal or...
Arboviral Encephalitis01:25

Arboviral Encephalitis

Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessment of Bedside-Adaptable Models to Predict Molecular Sepsis Subtypes in a Resource-Limited Setting: A Multicenter Analysis from Uganda.

medRxiv : the preprint server for health sciences·2026
Same author

Long-term protection following a primary series of hepatitis B vaccine in Alaska Native children and adults.

Hepatology communications·2026
Same author

Patterns of antibiotic use for acute febrile illness in resource-limited settings: a multicenter study in DR Congo, Kenya and Uganda.

Frontiers in public health·2026
Same author

Remdesivir triphosphate as a potential repurposed drug against the emerging Bundibugyo Ebolavirus 2026.

The Journal of infection·2026
Same author

Identification of a unique humoral immune signature of Sudan ebolavirus persistence in human survivors.

Research square·2026
Same author

Sudan Virus Disease in Uganda, 2025.

The New England journal of medicine·2026
Same journal

Detection of and Early Genomic Insights into Chikungunya Virus, Bolivia, 2025.

Emerging infectious diseases·2026
Same journal

Household Transmission of Enterovirus D68, Washington and Oregon, United States, 2022-2024.

Emerging infectious diseases·2026
Same journal

New World Ocular Dirofilariasis Caused by Dirofilaria repens Infection, United States.

Emerging infectious diseases·2026
Same journal

Angiostrongylus cantonensis Rat Lungworm Detected in Rats, Madagascar, 2022-2023.

Emerging infectious diseases·2026
Same journal

Human Pulmonary Dirofilariasis,
North Queensland, Australia, 2023<sup>1</sup>.

Emerging infectious diseases·2026
Same journal

Trends in Congenital Syphilis Cases by Maternal Country of Birth, Spain, 2016-2024.

Emerging infectious diseases·2026
See all related articles

Related Experiment Video

Updated: Jun 17, 2026

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
10:28

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

Published on: June 26, 2020

Hepatitis E epidemic, Uganda.

Eyasu H Teshale1, Christopher M Howard, Scott P Grytdal

  • 1Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Mailstop G37, Atlanta, GA 30333, USA. eht4@cdc.gov

Emerging Infectious Diseases
|December 25, 2009
PubMed
Summary
This summary is machine-generated.

A large hepatitis E epidemic began in Uganda in 2007, becoming one of the world's biggest. By 2009, it infected over 10,000 people and caused 160 deaths.

More Related Videos

Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA
04:11

Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA

Published on: December 15, 2023

Related Experiment Videos

Last Updated: Jun 17, 2026

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
10:28

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

Published on: June 26, 2020

Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA
04:11

Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA

Published on: December 15, 2023

Area of Science:

  • Epidemiology
  • Infectious Diseases
  • Public Health

Background:

  • An unprecedented epidemic of hepatitis E (HE) emerged in Kitgum District, northern Uganda, in October 2007.
  • This region had no prior documented history of HE epidemics, highlighting the novelty and scale of the event.
  • The outbreak rapidly escalated, becoming one of the most significant HE epidemics globally.

Purpose of the Study:

  • To document the emergence and scale of the hepatitis E epidemic in Kitgum District, Uganda.
  • To analyze the initial impact of the outbreak in terms of morbidity and mortality.
  • To provide baseline data for understanding large-scale hepatitis E outbreaks in previously unaffected areas.

Main Methods:

  • Surveillance data collection from affected populations in Kitgum District.
  • Case ascertainment and reporting of illness and deaths related to hepatitis E.
  • Epidemiological analysis of outbreak trends from October 2007 to June 2009.

Main Results:

  • The hepatitis E epidemic affected over 10,196 individuals by June 2009.
  • A total of 160 deaths were attributed to the epidemic during the study period.
  • The outbreak represented a major public health crisis in northern Uganda.

Conclusions:

  • The 2007 Kitgum District hepatitis E outbreak was a massive epidemic with significant mortality.
  • The findings underscore the potential for widespread HE transmission in vulnerable populations.
  • Further research is needed to understand the drivers and long-term implications of such large-scale outbreaks.