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A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
08:50

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

Chorioamnionitis--a complex pathophysiologic syndrome.

R Menon1, R N Taylor, S J Fortunato

  • 1Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA. rmenon3@emory.edu

Placenta
|December 25, 2009
PubMed
Summary
This summary is machine-generated.

Chorioamnionitis, an inflammation of fetal membranes, is common but poorly understood. This review explores inflammation, apoptosis, and genetics to offer a novel perspective on its causes and early indicators.

Related Experiment Videos

Last Updated: Jun 17, 2026

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
08:50

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

Area of Science:

  • Obstetrics and Gynecology
  • Perinatal Medicine
  • Inflammatory Diseases

Background:

  • Chorioamnionitis, inflammation of the amniochorionic membrane, is a frequent pregnancy complication.
  • Its complex etiology and lack of early indicators hinder effective clinical intervention.
  • Existing reviews focus on histologic and clinical evidence, necessitating a novel approach.

Purpose of the Study:

  • To provide a novel perspective on chorioamnionitis.
  • To synthesize recent evidence on inflammation, apoptosis, and genetics related to chorioamnionitis.
  • To highlight the need for a coordinated approach to understand causality and identify early indicators.

Main Methods:

  • Comprehensive literature review of recent scientific evidence.
  • Focus on inflammation, apoptosis, and genetic factors.
  • Analysis of molecular and pathophysiological insights.

Main Results:

  • Identified gaps in understanding specific etiologies of chorioamnionitis.
  • Highlighted the challenge posed by the lack of early clinical and biomarker indicators.
  • Synthesized diverse factors including genetic, epigenetic, behavioral, and psychosocial influences.

Conclusions:

  • A deeper understanding of inflammation, apoptosis, and genetics is crucial for advancing chorioamnionitis research.
  • A coordinated approach is needed to unravel causality and develop early diagnostic tools.
  • Novel perspectives are essential for improving clinical interventions and patient outcomes in chorioamnionitis.