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Design and synthesis of selective inhibitors of placental alkaline phosphatase

Marion Lanier1, Eduard Sergienko, Ana Maria Simão

  • 1Human BioMolecular Research Institute, 5310 Eastgate Mall, San Diego, CA 92121-2804, USA. mlanier@hbri.org

Bioorganic & Medicinal Chemistry
|December 25, 2009
PubMed

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Enzyme Inhibition

Inhibitors are molecules that reduce enzyme activity by binding to the enzyme. In a normally functioning cell, enzymes are regulated by a variety of inhibitors. Drugs and other toxins can also inhibit enzymes. Some inhibitors bind to the enzyme’s active site, while others inhibit enzymatic activity by binding to other sites on the protein structure.