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Related Concept Videos

Introduction to Metabolism01:30

Introduction to Metabolism

Metabolism encompasses all biochemical reactions in a living organism, facilitating both the breakdown and synthesis of biomolecules. These metabolic processes are categorized into catabolic and anabolic pathways, which operate in a coordinated manner to ensure energy balance and cellular function.Catabolic Pathways and Energy ReleaseCatabolic pathways involve the breakdown of complex macromolecules such as carbohydrates, lipids, and proteins into smaller structures like monosaccharides, fatty...
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Living cells constantly carry out various chemical reactions which are necessary for their proper functioning. These reactions are interlinked to one another via multiple pathways. The collection of these chemical reactions is known as metabolism.
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Updated: Jun 17, 2026

A Strategy for Sensitive, Large Scale Quantitative Metabolomics
14:18

A Strategy for Sensitive, Large Scale Quantitative Metabolomics

Published on: May 27, 2014

Metabolomics: ready for the prime time?

Manuel Mayr1

  • 1Cardiovascular Division, King's College, London School of Medicine, King's College London, UK. manuel.mayr@kcl.ac.uk

Circulation. Cardiovascular Genetics
|December 25, 2009
PubMed
Summary
This summary is machine-generated.

Metabolomics, the study of small molecules, offers a holistic view beyond genetics for understanding diseases. This approach is crucial for cardiovascular research, enabling biomarker discovery and integrated treatment strategies.

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A Strategy for Sensitive, Large Scale Quantitative Metabolomics
14:18

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Published on: May 27, 2014

Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry (UPLC-MS)
07:34

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Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
11:02

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

Published on: November 29, 2024

Area of Science:

  • Metabolomics and its growing role in contemporary scientific research.
  • Focus on small-molecule metabolites as key indicators of biological processes.

Background:

  • Classic genetics links DNA to phenotypes; metabolomics complements this by measuring gene effects.
  • Transcriptional or protein profiles do not always correlate with metabolite concentrations, highlighting the need for direct metabolite measurement.
  • Metabolomics is poised for increased application in cardiovascular research.

Purpose of the Study:

  • To emphasize the importance of measuring small-molecule metabolites.
  • To explore the potential of metabolomics in cardiovascular research for biomarker identification and pathway analysis.
  • To advocate for a holistic approach in translating basic science to clinical applications for cardiovascular diseases.

Main Methods:

  • Defining the metabolome as the total complement of small-molecule metabolites.
  • Distinguishing between endogenous and exogenous metabolomes.
  • Highlighting the need for quantitative and qualitative assessment of metabolites in complex biological samples.

Main Results:

  • The number of endogenous metabolites is approximately a few thousand.
  • The exogenous metabolome is significantly larger than the endogenous metabolome.
  • Gene or protein expression may not directly correlate with metabolite concentrations.

Conclusions:

  • Metabolomics provides a crucial readout at the metabolite level, complementing genomic and proteomic data.
  • The holistic nature of metabolomics offers new strategies for cardiovascular disease prevention and treatment.
  • Metabolomic profiling enables a comprehensive assessment of metabolites in biological samples.