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Published on: February 28, 2012
Epidemiology of subtherapeutic anticoagulation in the United States
Adam J Rose1, Al Ozonoff, Richard W Grant
1Center for Health Quality, Outcomes, and Economic Research, Bedford VA Medical Center, Bedford, MA 01730, USA. adamrose@bu.edu
Background:
Low international normalized ratio (INR;
Methods And Results:
We prospectively collected data from 47 community-based clinics located throughout the United States from 2000 to 2002. We examined risk factors for low INR (
Conclusions:
In this cohort of patients receiving warfarin, more than 1 in 5 thromboembolic events occurred during a period of low INR. Women and patients anticoagulated for venous thromboembolism were particularly likely to experience low INR. Improving adherence, minimizing interruptions of therapy, and addressing low INR more promptly could reduce the risk of low INR.
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