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Reference ranges for interrupter resistance technique: the Asthma UK Initiative.
P J F M Merkus1, J Stocks, N Beydon
1Division of Respiratory Medicine, Dept of Paediatrics, Radboud University Medical Centre, Nijmegen Medical Centre, Nijmegen, The Netherlands.
The European Respiratory Journal
|December 25, 2009
Summary
New reference equations for interrupter resistance (Rint) in children are now available. These equations, based on a large dataset, improve the accuracy of this non-invasive lung function test for pediatric use.
Area of Science:
- Pediatric Pulmonology
- Respiratory Physiology
Background:
- Interrupter resistance (Rint) is a valuable, non-invasive lung function test for children.
- Existing reference equations for Rint lack robustness, hindering accurate interpretation.
Purpose of the Study:
- To develop reliable, sex-specific reference equations for Rint in healthy children.
- To assess the impact of methodological variations on predicted Rint values.
Main Methods:
- Collated Rint data from healthy children (N=1090 for expiratory, N=629 for inspiratory) from various sources.
- Utilized the LMS (lambda, mu, sigma) method to construct reference equations.
- Identified height as the primary predictor for Rint.
Main Results:
- Developed robust, sex-specific reference equations for expiratory and inspiratory Rint.
- Height was confirmed as the strongest independent predictor of Rint.
- Observed clinically insignificant differences between centers.
Conclusions:
- The newly developed Rint reference equations provide a more accurate basis for assessing pediatric lung function.
- These equations enhance the clinical utility of Rint testing in young children.
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