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Temperature modulation of slow and fast cortical rhythms.

R Reig1, M Mattia, A Compte

  • 1Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.

Journal of Neurophysiology
|December 25, 2009
PubMed
Summary

Temperature significantly impacts cortical network activity. Physiological temperatures (36-37°C) are crucial for brain slice activity to mimic in vivo conditions, influencing rhythmic patterns and firing rates.

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Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Biophysics

Background:

  • Spontaneous cortical network activity exhibits rhythmic patterns, including slow (<1 Hz) up/down states and faster (10-80 Hz) rhythms during up states.
  • Temperature is a critical environmental factor influencing cellular and network function in biological systems.

Purpose of the Study:

  • To investigate the effect of temperature variations on spontaneous emergent activity in local cortical networks.
  • To determine the optimal temperature range for in vitro cortical slice recordings to reflect in vivo conditions.

Main Methods:

  • Cortical slices were maintained in a bath with temperatures ranging from 26°C to 41°C.
  • Emergent network activity, including up/down state durations, firing rates, and rhythmicity, was recorded and analyzed.

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  • The impact of temperature on network transition speeds and wave propagation was assessed.

    • Main Results:

    • Temperature strongly modulated network activity: warmer temperatures shortened up states and increased firing rates, while cooling lengthened up states.
    • Down states were shortest at physiological temperatures (36-37°C), with merging of up/down states observed around 30°C.
    • Below 30°C, firing lost rhythmicity, becoming continuous; fast rhythms and high-frequency fluctuations were maximal at physiological temperatures.

    Conclusions:

    • Maintaining cortical slices at physiological temperature is essential for generating activity analogous to in vivo conditions.
    • Temperature variations alter the functional regimes of in vitro cortical networks, impacting activity generation and control mechanisms.
    • Observed temperature effects are independent of oxygenation changes.