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Updated: Jun 17, 2026
Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Association between arterial stiffness and estimated glomerular filtration rate in the Japanese general population
Takuro Kubozono1, Masaaki Miyata, Kiyo Ueyama
1Department of Cardiovascular, Respiratory and Metabolic Medicine, Kagoshima University, Japan.
Insights
Chronic kidney disease (CKD) is linked to arterial stiffness. This study found the cardio-ankle vascular index (CAVI) independently predicts reduced estimated glomerular filtration rate (eGFR) in the general population.
Area of Science:
- Cardiovascular Medicine
- Nephrology
- Public Health
Background:
- Chronic kidney disease (CKD) is a known risk factor for cardiovascular disease.
- The independent association between CKD and arterial stiffness in the general population requires further investigation.
Purpose of the Study:
- To determine the correlation between the cardio-ankle vascular index (CAVI) and estimated glomerular filtration rate (eGFR) in a general population.
- To assess if CKD is an independent risk factor for arterial stiffness.
Main Methods:
- 881 subjects undergoing health checkups were analyzed.
- Cardio-ankle vascular index (CAVI) was calculated using pulse volume, blood pressure, and vascular length.
- Chronic kidney disease (CKD) was evaluated using estimated glomerular filtration rate (eGFR).
Main Results:
- CAVI showed a significant negative correlation with eGFR.
- Multiple regression analysis revealed CAVI as an independent determinant of eGFR, adjusted for traditional risk factors.
- Progressive deterioration of CKD was associated with stepwise increments in CAVI.
Conclusions:
- Arterial stiffness, measured by CAVI, is independently correlated with eGFR.
- These findings indicate that CKD is associated with arterial stiffness in the general population.
Aim:
Chronic kidney disease (CKD) is associated with an increased risk of cardiovascular disease, although it has yet to be established whether CKD is an independent risk factor for arterial stiffness in community residents. The purpose of this study was to determine the correlation between the cardio-ankle vascular index (CAVI) and estimated glomerular filtration rate (eGFR) in the general population.
Methods:
We studied 881 consecutively enrolled subjects undergoing health checkups. CAVI was calculated automatically from the pulse volume record, blood pressure and the vascular length from the heart to the ankle. CKD was evaluated by the eGFR.
Results:
The distribution of eGFR was as follows: 241 with eGFR (mL/min/1.73m(2)) > or =90; 572 with eGFR 60-89; 65 with eGFR 30-59; 3 with eGFR 15-29; 0 with eGFR <15. Linear regression analysis showed that CAVI was negatively correlated significantly with eGFR, while multiple regression analysis using CAVI as an objective variable, adjusted for conventional atherosclerotic risk factors and eGFR as explanatory variables, demonstrated that CAVI was an independent determinant of eGFR. We also showed that stepwise increments of CAVI occurred with progressive deterioration of CKD.
Conclusion:
CAVI was independently correlated with eGFR indicating that CKD is associated with arterial stiffness in the general population.
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