Relationship of job satisfaction, psychological distress and stress-related biological parameters among healthy
Monica Amati1, Marco Tomasetti, Marida Ciuccarelli
1Department of Molecular Pathology and Innovative Therapies, Clinic of Occupational Medicine, Polytechnic University of Marche, Ancona, Italy. m.amati@univpm.it
Objective:
To examine the relationship between job satisfaction, psychological distress, psychosocial processes and stress-related biological factors, and to evaluate whether over time changes of work satisfaction could affect the immunological-inflammatory status of workers.
Methods:
One hundred and one nurses were enrolled at the Clinic of Occupational Medicine, Polytechnic University of Marche, Ancona, Italy. Perceived job satisfaction, psychological distress, and social support were assessed every 4 mo over a 1-yr period using 4 self-reported questionnaires. T lymphocytes CD3, CD4(+), CD8(+), CD8(+)-CD57(+), B lymphocyte CD19(+), NK cells CD56(+), and NK cell activity were determined.
Results:
Job satisfaction was associated with reduced psychological distress and was characterized by low cell numbers of CD8(+) suppressor T cells, CD8(+)-CD57(+) activated T cells, CD56(+) NK cells and low IL-6 levels. Over time changes in psychological parameters were related to changes in the immunological-inflammatory variables. Subjects who increased their job satisfaction showed a reduced psychological stress associated with reduced number of CD8(+)-CD57(+) activated T cells and inflammatory cytokines.
Conclusions:
Job (dis)satisfaction is related with psychological mechanisms in stress affecting cellular immune function.
Related Concept Videos
Psychoneuroimmunology: Cardiovascular Disease
A key area of focus in PNI is the relationship between stress and coronary...
Stress and Mental Health
Individuals with depression often experience challenges in both their personal and professional...
Psychological Responses to Stress
Physiological Foundation of Stress
Role of the Sympathetic Nervous System
Adrenaline triggers the...
Social Relationships and Well-Being
Introduction to Stress and Lifestyle

