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Synthesis and antimicrobial activity of some pyridinium salts
Vildan Alptüzün1, Sülünay Parlar, Hüseyin Taşli
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ege University, 35100, Bornova, Izmir, Turkey. vildan.alptuzun@ege.edu.tr
Abstract:
Some substituted benzylidenehydrazinylpyridinium derivatives bearing benzyl, ethylphenyl and propylphenyl groups on the pyridinium nitrogen were synthesized and screened for possible antibacterial and antifungal activities against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans using the microdilution method. Antimicrobial test results indicated that compounds containing a 3-phenylpropyl chain displayed the highest antimicrobial activity against Staphylococcus aureus and the compound 3d was the most active in the series against all tested bacteria and fungi strains.
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