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Updated: Jun 17, 2026
07:42
Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
Published on: April 26, 2012
Severe ifosfamide-induced neurotoxicity: a case report
Sara Ramos Linares1, Joaquín Breña Atienza, Matilde Cháfer Rudilla
1Pharmacy Department, Hospital Universitario Nuestra Señora de Candelaria, Carretera del Rosario n masculine 145. 38010, Santa Cruz de Tenerife, Spain. sramlin@gobiernodecanarias.org
Pharmacy World & Science : PWS
|December 25, 2009
Summary
Ifosfamide, an alkylating agent, can cause severe neurotoxicity in cancer patients. Early recognition and management of risk factors are crucial for patient safety during chemotherapy.
Area of Science:
- Oncology
- Pharmacology
- Neuroscience
Background:
- Ifosfamide is a vital alkylating agent for treating various cancers.
- Accumulation of ifosfamide metabolites can lead to significant neurotoxicity.
Observation:
- A case report details a patient with Hodgkin's lymphoma experiencing severe neurological toxicity after ifosfamide treatment.
- The patient had prior cisplatin chemotherapy, low albumin, and rapid ifosfamide infusion.
Findings:
- Neurological toxicity resolved with supportive care within three weeks.
- Risk factors identified include prior cisplatin, hypoalbuminemia, and rapid infusion of ifosfamide.
Implications:
- Clinicians must be vigilant for severe neurological toxicity associated with ifosfamide.
- Identifying and managing risk factors may mitigate ifosfamide-induced neurotoxicity.
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